Simultaneous determination of amlodipine and lisinopril dihydrate using fourth derivative spectroscopy

نویسندگان

چکیده

A new fast and simple selective method for the simultaneous determination of lisinopril dihydrate amlodipine in combined drugs was developed using fourth derivative spectrum method, based on zero-crossing-point technique compounds drugs. The wavelength values solvent medium were found to be (203, 207, 231 nm) (215, 254, 277 nm), respectively, with average obeying Beer’s law range 2.0 45.0 µg/mL 35.0 µg/mL. Lisinopril has molar absorptivity regions (9227.76-11700.28 L/mol.cm, 203 (15320.74-20795.59 207 (2207.60-3311.40 while (5886.72-10914.96 215 (5518.8-6418.16 254 (1676.08-1921.36 nm). recovery rate pharmaceutical dosage forms 95.13 102.60% 95.14 102.80%. results relative error showed that interferences did not affect estimating these compounds. proposed been successfully applied estimate forms.

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ژورنال

عنوان ژورنال: European Journal of Chemistry

سال: 2023

ISSN: ['2153-2249', '2153-2257']

DOI: https://doi.org/10.5155/eurjchem.14.1.65-71.2367